Peroxiredoxin 2 Peptide 1
Rabbit Monoclonal Antibody
Peptide, Recombinant Full-length, Endogenous
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org). The subcellular location is supported by literature. Immunofluorescent staining of human cell line THP-1 shows localization to cytosol. Human assay: THP-1 fixed with PFA, dilution: 1:100
Human assay: U2OS fixed with PFA, dilution: 1:100
Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Indirect ELISA (ie, binding of Antibody to full-length Antigen coated on plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Presumed Positive (with additional bands)
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org). Band of predicted size in kDa (+/-20%) with additional bands present.
Analysis performed using a standard panel of samples. Antibody Dilution 1:500
Western Blot using CPTC-PRDX2-1 as primary Ab against full-length recombinant Ag 10333 (lane 2). Also included are molecular wt. standards (lane 1) and the PRDX2-1 Ab as positive control (lane 3).
Western Blot using CPTC-PRDX2-1 as primary Ab against lysates from six breast cancer cell lines from the NCI60 cell line collection (lanes 2-7). Also included are molecular wt. standards (lane 1).
NCI Identification Number:
Peroxiredoxin 2 Peptide 1
CPTC-PRDX2 Peptide 1
NKEFB; PRP; TDPX1; TSA; PRX2; PRXII; Natural Killer Cell-Enhancing Factor B; Thioredoxin-Dependent Peroxide Reductase 1; NKEF-B; EC 18.104.22.168; MGC4104; PTX1; TPX1; Peroxiredoxin-2; Thiol-Specific Antioxidant 1; Torin; EC 1.11.1
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the
thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
UniProt Accession Number:
Calculated Isoelectric Point:
No SOPs available.
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