Background
Catalog Number:
CPTC-POLE-1
Target Antigen:
DNA Polymerase Epsilon, Catalytic Subunit Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/24/2025
Antigen Recognition(s):
Peptide
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00568
Antigen Name:
DNA Polymerase Epsilon, Catalytic Subunit Peptide 1
CPTC Name:
CPTC-POLE Peptide 1
Aliases:
DNA Polymerase Epsilon, Catalytic Subunit; POLE1; DNA Polymerase Epsilon Catalytic Subunit A; Polymerase (DNA) Epsilon, Catalytic Subunit; DNA Polymerase II Subunit A; 3'-5' Exodeoxyribonuclease; EC 2.7.7.7; Polymerase (DNA Directed), Epsilon, Catalytic Subunit; DNA Polymerase Epsilon Catalytic Subunit Protein; Polymerase (DNA Directed), Epsilon; EC 3.1.11.; EC 2.7.7; CRCS12; IMAGEI; FILS
Function:
This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature.POLE (DNA Polymerase Epsilon, Catalytic Subunit) is a Protein Coding gene. Diseases associated with POLE include Facial Dysmorphism, Immunodeficiency, Livedo, And Short Stature and Colorectal Cancer 12. Among its related pathways are Base excision repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding.Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, 27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). ( DPOE1_HUMAN,Q07864)
Chromosomal Localization:
12q24.33
Accession Number:
UniProt Accession Number:
Q07864
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
AIPLAIFQAEPTVR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1540
Last Updated:
01/08/2025
Links
- EnsEMBL - EnsEMBL POLE
- Uniprot - Uniprot Q07864
Characterization Data
SOPs
No SOPs available.
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