Partner And Localizer Of BRCA2 Peptide 1


Background

Catalog Number:

CPTC-PALB2-1

Target Antigen:

Partner And Localizer Of BRCA2 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

10/22/2019

Antigen Recognition(s):

Peptide, Phosphorylation

Thematic Panel(s):

DNA Damage Response (DDR) Pathway

SOP:

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image mmuno-MRM chromatogram of CPTC-PALB2-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3284) Click image to enlarge

CPTC-PALB2-1 iMRM

Result: Positive

mmuno-MRM chromatogram of CPTC-PALB2-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3284)


Background

NCI Identification Number:

00197

Antigen Name:

Partner And Localizer Of BRCA2 Peptide 1

CPTC Name:

CPTC-PALB2 Peptide 1

Keywords:

Partner And Localizer Of BRCA2; FANCN; Fanconi Anemia, Complementation Group N; PNCA3

Function:

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

PALB2 (Partner And Localizer Of BRCA2) is a Protein Coding gene. Diseases associated with PALB2 include Pancreatic Cancer 3 and Fanconi Anemia, Complementation Group N. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-Loop Structures.

Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity.

Chromosomal Localization:

16p12.2

NCBI Accession Number:

NP_078951.2

Swiss Prot Accession Number:

Q86YC2

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

NENLQESEIL(pS)QPK (pS376)

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1540

Last Updated:

11/13/2019

Links

Characterization Data

SOPs

No SOPs available.

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