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Nudix Hydrolase 16 Like 1 Peptide 1

Antibody: CPTC-NUDT16L1-1
Background

Catalog Number:

CPTC-NUDT16L1-1

Target Antigen:

Nudix Hydrolase 16 Like 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

02/09/2024

Antigen Recognition(s):

Peptide

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Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (299.3 KB)

CPTC-NUDT16L1-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


Characterization SOP Files

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Antigen: Nudix Hydrolase 16 Like 1 Peptide 1
Background

NCI Identification Number:

00423

Antigen Name:

Nudix Hydrolase 16 Like 1 Peptide 1

CPTC Name:

CPTC-NUDT16L1 Peptide 1

Aliases:

Nudix Hydrolase 16 Like 1; SDOS; TIRR; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16-Like 1; Tudor-Interacting Repair Regulator Protein; NUDT16-Like Protein 1; Protein Syndesmos; Syndesmos; NUDT16L1

Function:

NUDT16L1 (Nudix Hydrolase 16 Like 1) is a Protein Coding gene. Diseases associated with NUDT16L1 include Encephalopathy, Ethylmalonic and Spastic Hemiplegia. Among its related pathways are Proteoglycans in cancer and Syndecan-4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT16.Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).

Chromosomal Localization:

16p13.3

Accession Number:

NP_115725.1

UniProt Accession Number:

Q9BRJ7

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LVEALAAATEK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1210

Last Updated:

09/20/2020

Links

Characterization Data

SOPs

No SOPs available.

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