Mucin 16 Peptide 1
Rabbit Recombinant Cloned Antibody
iMRM screening of CPTC-MUC16-1 against synthetic peptide ELGPYTLDR (Mucin 16 Peptide 1)
Data provided by the Carr Lab, Broad Institute
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Western blot using CPTC-MUC16-1 as primary antibody cell lysates OVCAR-3 (lane 2), OVCAR-4 (lane 3), OVCAR-8 (lane 4), and SK-OV-3 (lane 5). Molecular weight standards are also included (lane 1). Expected molecular weight > 250 kDa.
NCI Identification Number:
Mucin 16 Peptide 1
CPTC-MUC16 Peptide 1
Mucin 16, Cell Surface Associated; CA125; Ovarian Cancer-Related Tumor Marker CA125; Ovarian Carcinoma Antigen CA125; Mucin-16; CA125 Ovarian Cancer Antigen; Mucin-16 Short Isoform; Mucin-16 Long Isoform; FLJ14303; MUC-16; CA-125; MUC16
This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include Ovarian Cyst and Clear Cell Adenocarcinoma. Among its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Metabolism of proteins.Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
UniProt Accession Number:
Calculated Isoelectric Point:
No SOPs available.
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