Marker Of Proliferation Ki-67 Peptide 2


Background

Catalog Number:

CPTC-MKI67-2

Target Antigen:

Marker Of Proliferation Ki-67 Peptide 2

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

03/08/2018

Antigen Recognition(s):

Peptide

SOP:

Background

NCI Identification Number:

00246

Antigen Name:

Marker Of Proliferation Ki-67 Peptide 2

CPTC Name:

CPTC-MKI67 Peptide 2

Keywords:

Marker Of Proliferation Ki-67; Antigen Identified By Monoclonal Antibody Ki-67; Protein Phosphatase 1, Regulatory Subunit 105; Antigen KI-67; Antigen Ki67; Proliferation-Related Ki-67 Antigen; Proliferation Marker Protein Ki-67; PPP1R105; MIB-1; MIB-; KIA

Function:

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. MKI67 (Marker Of Proliferation Ki-67) is a Protein Coding gene. Diseases associated with MKI67 include Cervical Intraepithelial Neoplasia and Bowen's Disease. Among its related pathways are Neuroscience and DNA Damage. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is CDCA2.Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Chromosomal Localization:

10q26.2

NCBI Accession Number:

NP_002408.2

Swiss Prot Accession Number:

P46013

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LDQPGNLPGSNR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1320

Last Updated:

11/14/2019

Links

Characterization Data

SOPs

No SOPs available.

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