Mitogen-Activated Protein Kinase Kinase 4 Peptide 1

CPTC-MAP2K4-1

Mitogen-Activated Protein Kinase Kinase 4 Peptide 1

IgG

Rabbit Monoclonal Antibody

05/12/2025

Peptide

00559

Mitogen-Activated Protein Kinase Kinase 4 Peptide 1

CPTC-MAP2K4 Peptide 1

Mitogen-Activated Protein Kinase Kinase 4; PRKMK4; SAPKK1; JNKK1; MEK4; MKK4; SKK1; JNKK; SEK1; Stress-Activated Protein Kinase Kinase 1; SAPK/ERK Kinase 1; MAPKK4; SERK1; Dual Specificity Mitogen-Activated Protein Kinase Kinase 4; C-Jun NH2-Terminal Kinase Kinase 1; C-Jun N-Terminal Kinase Kinase 1; JNK-Activating Kinase 1; MAP Kinase Kinase 4; MAPK/ERK Kinase 4; EC 2.7.12.2; SAPKK-1; MAPKK 4; MEK 4; JNK-Activated Kinase 1; SAPK Kinase 1

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP2K4 include Colorectal Cancer and Breast Cancer. Among its related pathways are Toll Like Receptor 3 (TLR3) Cascade and Prolactin Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K7.Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

17p12

P45985

N/A

Synthetic Peptide

N/A

1100

10/04/2024