Background
Catalog Number:
CPTC-LAG3-1
Target Antigen:
Lymphocyte Activating 3 Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/24/2025
Antigen Recognition(s):
Peptide
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00571
Antigen Name:
Lymphocyte Activating 3 Peptide 1
CPTC Name:
CPTC-LAG3 Peptide 1
Aliases:
Lymphocyte Activating 3; CD223; Lymphocyte Activation Gene 3 Protein; Lymphocyte-Activation Gene 3; CD223 Antigen; LAG-3; FDC
Function:
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. Diseases associated with LAG3 include Kyphoscoliotic Heart Disease and Endocervical Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and MHC class II protein binding. An important paralog of this gene is IL1RL1.Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:20421648, 7805750, 8647185). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:20421648, 7805750, 8647185). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear.[Secreted lymphocyte activation gene 3 protein]: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
Chromosomal Localization:
12p13.31
Accession Number:
UniProt Accession Number:
P18627
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
FVWSSLDTPSQR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1320
Last Updated:
01/23/2025
Links
- Uniprot - Uniprot P18627
Characterization Data
SOPs
No SOPs available.
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