Background
Catalog Number:
CPTC-IL16-1
RRID:
AB_2890087
Target Antigen:
Interleukin 16 Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/06/2024
Antigen Recognition(s):
Peptide, Recombinant Full-length, Endogenous
Purchase
- DSHB CPTC-IL16-1
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00374
Antigen Name:
Interleukin 16 Peptide 1
CPTC Name:
CPTC-IL16 Peptide 1
Aliases:
Interleukin 16; Lymphocyte Chemoattractant Factor; Pro-Interleukin-16; Prointerleukin 16; PrIL-16; LCF; Interleukin 16 (Lymphocyte Chemoattractant Factor); Neuronal Interleukin 16; HsT19289; FLJ42735; FLJ16806; PRIL16; NIL16; IL-16; IL16
Function:
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants.IL16 (Interleukin 16) is a Protein Coding gene. Diseases associated with IL16 include Whipple Disease and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is PDZD2.Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. [Isoform 1]: may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Chromosomal Localization:
15q25.1
Accession Number:
NP_004504.3
UniProt Accession Number:
Q14005
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
LLSTQAEESQGPVLK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1650
Last Updated:
09/02/2020
Links
- EnsEMBL - EnsEMBL IL16
- Entrez - Entrez IL16
- Uniprot - Uniprot Q14005
Characterization Data
SOPs
No SOPs available.
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