Background
Catalog Number:
CPTC-GSTP1-1
RRID:
AB_2617266
Target Antigen:
Glutathione S-Transferase Pi 1 Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
10/20/2023
Antigen Recognition(s):
Peptide
Thematic Panel(s):
DNA Damage Response (DDR) Pathway
External Links
- CPTAC Assay Portal CPTAC-3231
- CPTAC Assay Portal CPTAC-701
Purchase
- DSHB CPTC-GSTP1-1
Publications
- A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage (PMID: 29474155)
- GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation (PMID: 34499222 )
- Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer (PMID: 33242424)
Characterization Data [Compare Characterization Data]
IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (465.3 KB)
CPTC-GSTP1-1 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Immuno-MRM
CPTC-GSTP1-1 IMRM
Result: Positive
Immuno-MRM chromatogram of CPTC-GSTP1-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3231)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)
Characterization SOP Files
Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (465.3 KB)
CPTC-GSTP1-1 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Indirect ELISA
CPTC-GSTP1-1 Indirect ELISA (peptide)
Result: Positive
Indirect ELISA (ie, binding of Antibody to Peptide coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Characterization SOP Files
Background
NCI Identification Number:
00028
Antigen Name:
Glutathione S-Transferase Pi 1 Peptide 1
CPTC Name:
CPTC-GSTP1 Peptide 1
Aliases:
GST3; FAEES3; GSTP; GSTP1-1; GST Class-Pi; EC 2.5.1.18; DFN7; PI; Deafness, X-Linked 7; Fatty Acid Ethyl Ester Synthase III; Glutathione S-Transferase P
Function:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic, xenobiotic substrates, thus aiding excretion from the body.
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Chromosomal Localization:
11q13.2
Accession Number:
AY324387.1
UniProt Accession Number:
P09211
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
YISLIYTNYEAGK
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
1430
Last Updated:
06/11/2013
Links
- EnsEMBL - EnsEMBL GSTP1
- Entrez - Entrez GSTP1
- Uniprot - Uniprot P09211
Characterization Data
SOPs
No SOPs available.
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