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GIT2 Gene Peptide 1

Antibody: CPTC-GIT2-1
Background

Catalog Number:

CPTC-GIT2-1

Target Antigen:

GIT2 Gene Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

07/19/2024

Antigen Recognition(s):

Peptide

Purchase
Characterization Data [Compare Characterization Data]
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Antigen: GIT2 Gene Peptide 1
Background

NCI Identification Number:

00482

Antigen Name:

GIT2 Gene Peptide 1

CPTC Name:

CPTC-GIT2 Peptide 1

Aliases:

GIT2 Gene; GIT ArfGAP 2; G Protein-Coupled Receptor Kinase Interacting ArfGAP 2; Cool-Interacting Tyrosine-Phosphorylated Protein 2; G Protein-Coupled Receptor Kinase-Interactor 2; ARF GTPase-Activating Protein GIT2; GRK-Interacting Protein 2; Paxillin Kinase Linker; ARF GAP GIT2; KIAA0148; CAT-2; CAT2; PKL; Cool-Associated, Tyrosine Phosphorylated Protein 2; G Protein-Coupled Receptor Kinase Interactor 2; GIT2

Function:

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.GIT2 (GIT ArfGAP 2) is a Protein Coding gene. Diseases associated with GIT2 include Esophagus Verrucous Carcinoma and Blind Loop Syndrome. Among its related pathways are Yersinia infection and MAPK Erk Pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is GIT1.

Chromosomal Localization:

12q24.11

Accession Number:

NP_476510.1

UniProt Accession Number:

Q14161

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

CLQPFPAHIGR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1210

Last Updated:

03/04/2021

Links

Characterization Data

SOPs

No SOPs available.

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