Fascin 1, Actin-Bundling Protein Peptide 1


Background

Catalog Number:

CPTC-FSCN1-1

Target Antigen:

Fascin 1, Actin-Bundling Protein Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

08/06/2019

Antigen Recognition(s):

Peptide

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-ATM-1 antibody (see CPTAC assay portal for details:  (https://assays.cancer.gov/CPTAC-709) Click image to enlarge

CPTC-FSCN 1-1 iMRM

Immuno-MRM chromatogram of CPTC-ATM-1 antibody (see CPTAC assay portal for details: (https://assays.cancer.gov/CPTAC-709)

Background

NCI Identification Number:

00041

Antigen Name:

Fascin 1, Actin-Bundling Protein Peptide 1

CPTC Name:

CPTC-FSCN1 Peptide 1

Keywords:

SNL; P55; 55 KDa Actin-Bundling Protein; FAN1; HSN; FLJ38511; Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like); Fascin; Singed-Like (Fascin Homolog, Sea Urchin); Singed-like protein

Function:

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into arallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a ritical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be egulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of
cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's ymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.

Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the
organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers.
Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and
migration

Chromosomal Localization:

7p22

NCBI Accession Number:

NP_003079.1

Swiss Prot Accession Number:

Q16658

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

YLAPSGPSGTLK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1320

Last Updated:

07/18/2019

Links

Characterization Data

SOPs

No SOPs available.

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