Fanconi Anemia Complementation Group I Peptide 1


Background

Catalog Number:

CPTC-FANCI-1

Target Antigen:

Fanconi Anemia Complementation Group I Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

04/26/2018

Antigen Recognition(s):

Peptide, Phosphorylation

SOP:

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-FANCI-1 antibody (see CPTAC assay portal for details:  https://assays.cancer.gov/CPTAC-3283) Click image to enlarge

CPTC-FANCI-1 iMRM

Immuno-MRM chromatogram of CPTC-FANCI-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3283)

Background

NCI Identification Number:

00232

Antigen Name:

Fanconi Anemia Complementation Group I Peptide 1

CPTC Name:

CPTC-FANCI Peptide 1

Keywords:

Fanconi Anemia Complementation Group I; KIAA1794; Fanconi Anemia Group I Protein; Protein FACI

Function:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.

FANCI (Fanconi Anemia Complementation Group I) is a Protein Coding gene. Diseases associated with FANCI include Fanconi Anemia, Complementation Group I and Fanconi Anemia, Complementation Group A. Among its related pathways are Fanconi anemia pathway and Gene Expression. GO annotations related to this gene include DNA polymerase binding.

Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.

Chromosomal Localization:

15q26.1

NCBI Accession Number:

NP_001106849.1

Swiss Prot Accession Number:

Q9NVI1

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

SADF(pS)QSTSIGIK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1430

Last Updated:

04/23/2018

Links

Characterization Data

SOPs

No SOPs available.

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