Fanconi Anemia, Complementation Group D2 Peptide 1


Background

Catalog Number:

CPTC-FANCD2-1

RRID:

AB_2888951

Target Antigen:

Fanconi Anemia, Complementation Group D2 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

02/15/2024

Antigen Recognition(s):

Peptide, Ubiquitination

Purchase
Characterization Data [Compare Characterization Data]
Background

Catalog Number:

CPTC-FANCD2-2

RRID:

AB_2888952

Target Antigen:

Fanconi Anemia, Complementation Group D2 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

03/20/2024

Antigen Recognition(s):

Peptide, Endogenous, Ubiquitination

External Links
Purchase
Publications
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-FANCD2-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3229 for unmodified peptide and https://assays.cancer.gov/CPTAC-3228  for ubiquinated peptide)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html). Data shown were obtained from cell lysate. Click image to enlarge

CPTC-FANCD2-2 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-FANCD2-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3229 for unmodified peptide and https://assays.cancer.gov/CPTAC-3228 for ubiquinated peptide)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html). Data shown were obtained from cell lysate.


Background

NCI Identification Number:

00094

Antigen Name:

Fanconi Anemia, Complementation Group D2 Peptide 1

CPTC Name:

CPTC-FANCD2 Peptide 1

Aliases:

FACD; FANCD; FAD, FA-D2; FA4; FAD2; Fanconi Anemia Group D2 Protein; Protein FACD2

Function:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.



Chromosomal Localization:

3025.3

Accession Number:

NP_001018125.1

UniProt Accession Number:

Q9BXW9

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

(K-ε-GG)QLSSTVFK (uK561)

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1210

Last Updated:

03/11/2015

Links

Characterization Data

SOPs

No SOPs available.

Don't have Adobe Reader™?

Get it for free at Adobe.com