Fanconi Anemia Complementation Group A Peptide 1


Background

Catalog Number:

CPTC-FANCA-1

Target Antigen:

Fanconi Anemia Complementation Group A Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

04/26/2018

Antigen Recognition(s):

peptide

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-FANCA-1 antibody (see CPTAC assay portal for details:  https://assays.cancer.gov/CPTAC-3226) Click image to enlarge

CPTC-FANCA-1 iMRM

Immuno-MRM chromatogram of CPTC-FANCA-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3226)

Background

NCI Identification Number:

00228

Antigen Name:

Fanconi Anemia Complementation Group A Peptide 1

CPTC Name:

CPTC-FANCA Peptide 1

Keywords:

Fanconi Anemia Complementation Group A; FANCH; FACA; FAA; Fanconi Anemia, Complementation Group H; Fanconi Anemia Group A Protein; Fanconi Anemia, Type 1; Protein FACA; FA-H; FA1; FAH; FA

Function:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.

FANCA (Fanconi Anemia Complementation Group A) is a Protein Coding gene. Diseases associated with FANCA include Fanconi Anemia, Complementation Group A and Fanca-Related Fanconi Anemia. Among its related pathways are Fanconi anemia pathway and Chks in Checkpoint Regulation.

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.

Chromosomal Localization:

16q24.3

Expression System:

NCBI Accession Number:

NP_000126

Swiss Prot Accession Number:

O15360

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

QQAAPDADLSQEPHLF

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1760

Last Updated:

07/20/2017

Links

Characterization Data

SOPs

No SOPs available.

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