Erb-B2 Receptor Tyrosine Kinase 3 Peptide 5


Background

Catalog Number:

CPTC-ERBB3-4

Target Antigen:

Erb-B2 Receptor Tyrosine Kinase 3 Peptide 5

Isotype:

IgG1

Species:

Mouse Monoclonal Antibody

Last Updated:

07/18/2019

Antigen Recognition(s):

SOP:

Purchase
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-ERRB3-4 antibody with CPTC-ERRB3 peptide 5 (NCI ID#00217) as target Click image to enlarge

CPTC-ERBB3-4 iMRM

Immuno-MRM chromatogram of CPTC-ERRB3-4 antibody with CPTC-ERRB3 peptide 5 (NCI ID#00217) as target

Background

NCI Identification Number:

00217

Antigen Name:

Erb-B2 Receptor Tyrosine Kinase 3 Peptide 5

CPTC Name:

CPTC-ERBB3 Peptide 5

Keywords:

Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; Receptor Tyrosine-Protein Kinase ErbB-3; P180-ErbB3; P45-SErbB3; P85-SErbB3; EC 2.7.10; MDA-BF-1; C-ErbB-3; C-ErbB3; ErbB3-S; ErbB-3; LCCS2

Function:

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contractural Syndrome 2 and Retroperitoneal Leiomyosarcoma. Among its related pathways are PI-3K cascade-FGFR3 and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERBB4.

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5.

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.

Chromosomal Localization:

12q13

NCBI Accession Number:

NP_001005915.1

Swiss Prot Accession Number:

P21860

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

SLEATDSAFDNPDYWHSR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1980

Last Updated:

02/28/2017

Links

Characterization Data

SOPs

No SOPs available.

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