Background
Catalog Number:
CPTC-CDH2-1
RRID:
AB_2722041
Target Antigen:
Cadherin 2 Peptide 2
Isotype:
IgG2b
Species:
Mouse Monoclonal Antibody
Last Updated:
10/04/2024
Antigen Recognition(s):
Peptide
Thematic Panel(s):
Ras Pathway
Purchase
- DSHB CPTC-CDH2-1
External Links
- Human Protein Atlas CPTC-CDH2-1
Publications
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (388.1 KB)
CPTC-CDH2-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Immuno-MRM
CPTC-CDH2-1 iMRM
Result: Positive
Immuno-MRM chromatogram of CPTC-CDH2-1 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target
Immunofluorescence - HPA
CPTC-CDH2-1 Evaluation by the Human Protein Atlas
Result: Positive
Results provided by the Human Protein Atlas (www.proteinatlas.org). The subcellular location is supported by literature. Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane. Human assay: THP-1 fixed with PFA, dilution: 1:100
Human assay: U2OS fixed with PFA, dilution: 1:100
Characterization SOP Files
NCI 60 Protein Array
CPTC-CDH2-1 NCI 60 Protein Array
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Characterization SOP Files
Background
Catalog Number:
CPTC-CDH2-2
RRID:
AB_2722042
Target Antigen:
Cadherin 2 Peptide 2
Isotype:
IgG3
Species:
Mouse Monoclonal Antibody
Last Updated:
10/04/2024
Antigen Recognition(s):
Peptide
Thematic Panel(s):
Ras Pathway
Purchase
- DSHB CPTC-CDH2-2
Publications
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (297.5 KB)
CPTC-CDH2-2 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Immuno-MRM
CPTC-CDH2-2 iMRM
Result: Positive
Immuno-MRM chromatogram of CPTC-CDH2-2 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target
NCI 60 Protein Array
CPTC-CDH2-2 NCI 60 Protein Array
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Characterization SOP Files
Background
Catalog Number:
CPTC-CDH2-3
RRID:
AB_2722043
Target Antigen:
Cadherin 2 Peptide 2
Isotype:
IgG2b
Species:
Mouse Monoclonal Antibody
Last Updated:
10/04/2024
Antigen Recognition(s):
Peptide
Thematic Panel(s):
Ras Pathway
Purchase
- DSHB CPTC-CDH2-3
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (308.6 KB)
CPTC-CDH2-3 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Immuno-MRM
CPTC-CDH2-3 iMRM
Result: Positive
Immuno-MRM chromatogram of CPTC-CDH2-2 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target
NCI 60 Protein Array
CPTC-CDH2-3 NCI 60 Protein Array
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Characterization SOP Files
Background
NCI Identification Number:
00173
Antigen Name:
Cadherin 2 Peptide 2
CPTC Name:
CPTC-CDH2 Peptide 2
Aliases:
Cadherin 2; Cadherin 2, Type 1, N-Cadherin (Neuronal); Neural Cadherin; N-Cadherin; CDw325; NCAD; CDHN; Calcium-Dependent Adhesion Protein, Neuronal; CD325 Antigen; N-Cadherin 1; Cadherin-2; CD325
Function:
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone.
CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Arrhythmogenic Right Ventricular Cardiomyopathy and Pseudomyxoma Peritonei. Among its related pathways are Blood-Brain Barrier Pathway: Anatomy and WNT Signaling. GO annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is CDH4.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Chromosomal Localization:
18q12.1
Accession Number:
XP_016881003.1
UniProt Accession Number:
P19022
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
LSDPANWLK
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
990
Last Updated:
10/01/2019
Links
- EnsEMBL - EnsEMBL CDH2
- Entrez - Entrez CDH2
- Uniprot - Uniprot P19022
Characterization Data
SOPs
No SOPs available.
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