Cadherin 2 Peptide 2


Background

Catalog Number:

CPTC-CDH2-1

RRID:

AB_2722041

Target Antigen:

Cadherin 2 Peptide 2

Isotype:

IgG2b

Species:

Mouse Monoclonal Antibody

Last Updated:

01/04/2023

Antigen Recognition(s):

Peptide

Thematic Panel(s):

Ras Pathway

Purchase
External Links
Publications
Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (388.1 KB)

CPTC-CDH2-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-CDH2-1 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target Click image to enlarge

CPTC-CDH2-1 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-CDH2-1 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target


  Immunofluorescence - HPA
Click to enlarge image Results provided by the Human Protein Atlas (www.proteinatlas.org). The subcellular location is supported by literature. Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane. Human assay: THP-1 fixed with PFA, dilution: 1:100
Human assay: U2OS fixed with PFA, dilution: 1:100 Click image to enlarge

CPTC-CDH2-1 Evaluation by the Human Protein Atlas

Result: Positive

Results provided by the Human Protein Atlas (www.proteinatlas.org). The subcellular location is supported by literature. Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane. Human assay: THP-1 fixed with PFA, dilution: 1:100
Human assay: U2OS fixed with PFA, dilution: 1:100


Background

Catalog Number:

CPTC-CDH2-2

RRID:

AB_2722042

Target Antigen:

Cadherin 2 Peptide 2

Isotype:

IgG3

Species:

Mouse Monoclonal Antibody

Last Updated:

08/24/2022

Antigen Recognition(s):

Peptide

Thematic Panel(s):

Ras Pathway

Purchase
Publications
Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (297.5 KB)

CPTC-CDH2-2 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-CDH2-2 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target Click image to enlarge

CPTC-CDH2-2 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-CDH2-2 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target


Background

Catalog Number:

CPTC-CDH2-3

RRID:

AB_2722043

Target Antigen:

Cadherin 2 Peptide 2

Isotype:

IgG2b

Species:

Mouse Monoclonal Antibody

Last Updated:

02/15/2024

Antigen Recognition(s):

Peptide

Thematic Panel(s):

Ras Pathway

Purchase
Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (308.6 KB)

CPTC-CDH2-3 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-CDH2-2 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target Click image to enlarge

CPTC-CDH2-3 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-CDH2-2 antibody with CPTC-CDH2 peptide 2 (NCI ID#173) as target


Background

NCI Identification Number:

00173

Antigen Name:

Cadherin 2 Peptide 2

CPTC Name:

CPTC-CDH2 Peptide 2

Aliases:

Cadherin 2; Cadherin 2, Type 1, N-Cadherin (Neuronal); Neural Cadherin; N-Cadherin; CDw325; NCAD; CDHN; Calcium-Dependent Adhesion Protein, Neuronal; CD325 Antigen; N-Cadherin 1; Cadherin-2; CD325

Function:

This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone.

CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Arrhythmogenic Right Ventricular Cardiomyopathy and Pseudomyxoma Peritonei. Among its related pathways are Blood-Brain Barrier Pathway: Anatomy and WNT Signaling. GO annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is CDH4.

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.

Chromosomal Localization:

18q12.1

Accession Number:

XP_016881003.1

UniProt Accession Number:

P19022

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LSDPANWLK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

990

Last Updated:

10/01/2019

Links

Characterization Data

SOPs

No SOPs available.

Don't have Adobe Reader™?

Get it for free at Adobe.com