Background
Catalog Number:
CPTC-CD86-1
Target Antigen:
CD86 Molecule Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
07/02/2025
Antigen Recognition(s):
Peptide
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00562
Antigen Name:
CD86 Molecule Peptide 1
CPTC Name:
CPTC-CD86 Peptide 1
Aliases:
CD86 Molecule; CD28LG2; B7.2; B7-2; CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen); T-Lymphocyte Activation Antigen CD86; CTLA-4 Counter-Receptor B7.2; FUN-1; BU63; B70; B-Lymphocyte Activation Antigen B7-2; B-Lymphocyte Antigen B7-2; Activation B7-2 Antigen; CD86 Antigen; LAB72
Function:
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Plague and Cowpox. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity. An important paralog of this gene is CD80.Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4 (PubMed:12196291). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). ( CD86_HUMAN,P42081 )[Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. ( CD86_HUMAN,P42081 ). (Microbial infection) Acts as a receptor for adenovirus subgroup B. ( CD86_HUMAN,P42081 )
Chromosomal Localization:
3q13.33
Accession Number:
UniProt Accession Number:
P42081
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
TSFDSDSWTLR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1210
Last Updated:
01/08/2025
Links
- EnsEMBL - EnsEMBL CD86
- Uniprot - Uniprot P42081
Characterization Data
SOPs
No SOPs available.
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