C-C Motif Chemokine Ligand 5 Peptide 1

CPTC-CCL5-1

C-C Motif Chemokine Ligand 5 Peptide 1

IgG1

Mouse Monoclonal Antibody

03/01/2024

Peptide

CPTC-CCL5-2

C-C Motif Chemokine Ligand 5 Peptide 1

IgG3

Mouse Monoclonal Antibody

03/20/2024

Peptide, Endogenous

Immuno-Oncology (IO)

00466

C-C Motif Chemokine Ligand 5 Peptide 1

CPTC-CCL5 Peptide 1

C-C Motif Chemokine Ligand 5; SIS-Delta; TCP228; Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5; Eosinophil Chemotactic Cytokine; Chemokine (C-C Motif) Ligand 5; T-Cell Specific Protein P288; Beta-Chemokine RANTES; C-C Motif Chemokine 5; D17S136E; RANTES; SCYA5; SISd; EoCP; Small Inducible Cytokine A5 (RANTES); T-Cell Specific RANTES Protein; T-Cell-Specific Protein RANTES; T Cell-Specific Protein P228; Small-Inducible Cytokine A5; MGC17164; CCL5

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Periapical Granuloma and Ulcer Of Lower Limbs. Among its related pathways are Signaling by GPCR and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL3L1.Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.

17q12

NP_002976.2

P13501

N/A

Synthetic Peptide

N/A

880

12/16/2020