Catalog Number:
CPTC-BCL2L1-1
RRID:
AB_10805150
Target Antigen:
BCL2 like 1
Isotype:
IgG2a
Species:
Mouse Monoclonal Antibody
Last Updated:
09/01/2022
Antigen Recognition(s):
Recombinant Full-length
Result: Positive
These are the results of SPR pairing experiments with BCL2L1 antibodies.
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Negative
This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.
Result: Negative
This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Result: Positive
Western Blot using CPTC-BCL2L1-1 as primary Ab against BCL2L1 (rAg 10650) in lane 2. Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
Catalog Number:
CPTC-BCL2L1-2
RRID:
AB_10804669
Target Antigen:
BCL2 like 1
Isotype:
IgG2b
Species:
Mouse Monoclonal Antibody
Last Updated:
09/01/2022
Antigen Recognition(s):
Recombinant Full-length, Endogenous
Result: Positive
These are the results of SPR pairing experiments with BCL2L1 antibodies.
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Negative
This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.
Result: Negative
This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.
Result: Positive
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Result: Positive
Western Blot using CPTC-BCL2L1-2 as primary Ab against BCL2L1 (rAg 10650) in lane 2. Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
Catalog Number:
CPTC-BCL2L1-3
RRID:
AB_10805874
Target Antigen:
BCL2 like 1
Isotype:
IgG2b
Species:
Mouse Monoclonal Antibody
Last Updated:
09/01/2022
Antigen Recognition(s):
Recombinant Full-length, Endogenous
Result: Positive
These are the results of SPR pairing experiments with BCL2L1 antibodies.
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Negative
This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.
Result: Negative
This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.
Result: Positive
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Result: Positive
Western Blot using CPTC-BCL2L1-3 as primary Ab against BCL2L1 (rAg 10650) in lane 2. Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
NCI Identification Number:
10650
Antigen Name:
BCL2 like 1
CPTC Name:
CPTC-BCL2L1
Aliases:
BCL2-like 1; BCLX; BCL2L; bcl-xL; Bcl-S; bcl-xS; Apoptosis regulator Bcl-X; BCLXL; BCLXS; BCL-XL/S; bcl2-L-1; bcl-2-like protein 1; Bcl2-L-1
Function:
Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell
death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the
caspase activator, CYC1, from the mitochondrial membrane
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the
production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2 proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes.
Chromosomal Localization:
20q11.21
Expression System:
E. Coli
Accession Number:
BC019307.1
UniProt Accession Number:
Q07817
DNA Source:
DNASU - HsCD00004711
Immunogen:
Recombinant Full Length Protein
Vector Name:
pMCSG7
Extinction Coefficient:
41940
Buffers:
PBS without Ca++ and Mg++
Expressed Sequence:
SNAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMET
PSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEF
ELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFG
GALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGN
NAAAESRKGQERF
Native Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSA
INGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELR
YRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGAL
CVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAA
AESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Calculated Isoelectric Point:
4.65
Molecular Weight:
23786
Last Updated:
05/04/2011
PAGE of BCL2L2 (rAg 10650) with molecular weight standards in lane 1
No SOPs available.
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