Background
Catalog Number:
CPTC-BCL10-1
RRID:
AB_2889953
Target Antigen:
BCL10 Immune Signaling Adaptor Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/02/2024
Antigen Recognition(s):
Peptide, Endogenous
Purchase
- DSHB CPTC-BCL10-1
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (282.5 KB)
CPTC-BCL10-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
NCI 60 Protein Array
CTPC-BCL10-1 NCI60 Protein Array
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Characterization SOP Files
Western Blot - Recombinant Protein or Peptide
CPTC-BCL10-1 Western Blot (recombinant protein)
Result: Negative
Western blot using CPTC-BCL10-1 as primary antibody against human BCL-10 recombinant protein (lane 2). Expected molecular weight - 28.8 kDa. Molecular weight standards are also included (lane 1).
Characterization SOP Files
Background
NCI Identification Number:
00347
Antigen Name:
BCL10 Immune Signaling Adaptor Peptide 1
CPTC Name:
CPTC-BCL10 Peptide 1
Aliases:
BCL10 Immune Signaling Adaptor; CIPER; C-E10; CLAP; ME10; CED-3/ICH-1 Prodomain Homologous E10-Like Regulator; Mammalian CARD-Containing Adapter Molecule E10; CARD-Containing Molecule Enhancing NF-Kappa-B; Caspase-Recruiting Domain-Containing Protein; CARD-Containing Apoptotic Signaling Protein; CARD Containing Molecule Enhancing NF-KB; CARD-Containing Proapoptotic Protein; CARD-Like Apoptotic Protein; B-Cell Lymphoma/Leukemia 10; Cellular Homolog Of VCARMEN; B Cell CLL/Lymphoma 10; Cellular-E10; CCARMEN; CARMEN; HCLAP; BCL10, Immune Signaling Adaptor; B-Cell CLL/Lymphoma 10; Bcl-10; IMD37; BCL10
Function:
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. BCL10 (BCL10 Immune Signaling Adaptor) is a Protein Coding gene. Diseases associated with BCL10 include Lymphoma, Mucosa-Associated Lymphoid Type and Immunodeficiency 37. Among its related pathways are B cell receptor signaling pathway (KEGG) and NF-KappaB Family Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and transcription factor binding.Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1
Chromosomal Localization:
1p22.3
Accession Number:
NP_003912.1
UniProt Accession Number:
O95999
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
GLDTLVESIR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1100
Last Updated:
09/02/2020
Links
- CPTAC Assay Portal - EnsEMBL BCL10
- CPTAC Assay Portal - Entrez BCL10
- Uniprot - Uniprot O95999
Characterization Data
SOPs
No SOPs available.
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