Background
Catalog Number:
CPTC-BAI1-1
RRID:
AB_2814781
Target Antigen:
Brain-Specific Angiogenesis Inhibitor 1 Peptide 1
Isotype:
IgG3
Species:
Mouse Monoclonal Antibody
Last Updated:
09/01/2022
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-BAI1-1
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (316.0 KB)
CPTC-BAI1-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
IP
CPTC-BAI1-1 IPMS
Result: Positive
Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-1 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen.
Immunofluorescence - HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (316.0 KB)
CPTC-BAI1-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Background
Catalog Number:
CPTC-BAI1-2
RRID:
AB_2814782
Target Antigen:
Brain-Specific Angiogenesis Inhibitor 1 Peptide 1
Isotype:
IgG3
Species:
Mouse Monoclonal Antibody
Last Updated:
09/01/2022
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-BAI1-2
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (573.9 KB)
CPTC-BAI1-2 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
IP
CPTC-BAI1-2 IPMS
Result: Positive
Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-2 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen.
Immunofluorescence - HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (573.9 KB)
CPTC-BAI1-2 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Background
Catalog Number:
CPTC-BAI1-3
RRID:
AB_2814783
Target Antigen:
Brain-Specific Angiogenesis Inhibitor 1 Peptide 1
Isotype:
IgG2b
Species:
Mouse Monoclonal Antibody
Last Updated:
09/01/2022
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-BAI1-3
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (568.4 KB)
CPTC-BAI1-3 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
IP
CPTC-BAI1-3 IPMS
Result: Positive
Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-3 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen.
Immunofluorescence - HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (568.4 KB)
CPTC-BAI1-3 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Background
NCI Identification Number:
00083
Antigen Name:
Brain-Specific Angiogenesis Inhibitor 1 Peptide 1
CPTC Name:
CPTC-BAI1 Peptide 1
Aliases:
Brain-Specific Angiogenesis Inhibitor 1; GDAIF
Function:
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.
BAI1 (brain-specific angiogenesis inhibitor 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is UNC5B.
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
Chromosomal Localization:
8q24.3
Accession Number:
NP_001693.2
UniProt Accession Number:
O14514
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
QFDSFLESTRTYLGVE
Native Sequence:
mrgqaaapgpvwilapllllllllgrraraaagadagpgpepcatlvqgk
ffgyfsaaavfpanasrcswtlrnpdprrytlymkvakapvpcsgpgrvr
tyqfdsflestrtylgvesfdevlrlcdpsaplaflqaskqflqmrrqqp
pqhdglrpragppgptddfsveylvvgnrn psraacqmlcrwldaclag
srsshpcgimqtpcaclggeaggpaagplaprgdvclrdavaggpenclt
sltqdrgghgatggwklwslwgectrdcggglqtrtrtclpapgvegggc
egvleegrqcnreacgpagrtssrsqslrstdarrreelgdelqqfgfpa
pqtgdpaaeew spwsvcsstcgegwqtrtrfcvsssystqcsgplreq
rlcnnsavcpvhgawdewspwslcsstcgrgfrdrtrtcrppqfggnpce
gpekqtkfcnialcpgravdgnwnewsswsacsascsqgrqqrtrecngp
syg gaecqghwvetrdcflqqcpvdgkwqawaswgscsvtcgagsqrre
rvcsgpffggaacqgpqdeyrqcgtqrcpepheicdednfgaviwketpa
gevaavrcprnatglilrrceldeegiaywepptyircvsidyrniqmmt
rehlakaqrglpgegvseviqtlveisqdgtsysgdllstidvlrnmtei
frrayysptpgdvqnfvqilsnllaeenrdkweeaqlagpnakelfrlve
dfvdvigfrmkdlrdayqvtdnlvlsihklpasgatdisfpmkgwratgd
wakvpedrvtvsksvfstglteadeasvfvvgtvlyrnlgsflalqrntt
vlnskvisvtvkppprslrtpleiefahmyngttnqtcilwdetdvpsss
appqlgpwswrgcrtvpldalrtrclcdrlstfailaqlsadanmekatl
psvtlivgcgvssltllmlviiyvsvwryirsersvilinfclsiissna
liligqtqtrnkvvctlvaaflhffflssfcwvlteawqsymavtghlrn
rlirkrflclgwglpalvvaisvgftkakgystmnycwlslegg llyaf
vgpaaavvlvnmvigilvfnklvskdgitdkklkeragaslwsscvvlpl
laltwmsavlavtdrrsalfqilfavfdslegfvivmvhcilrrevqdav
kcrvvdrqeegngdsggsfqnghaqlmtdfekdvdlacrsvlnkdiaacr
tatitgtlkrpslpeeeklklahakgpptnfnslpanvsklhlhgspryp
ggplpdfpnhsltlkrdkapkssfvgdgdifkkldselsraqekaldtsy
vilptatatlrpkpkeepkysihidqmpqtrlihlstapeaslparspps
rqppsggppeappaqppppppppppppqqplppppnlepappslgdpgep
aahpgpstgpstknenvatlsvssl errksryaeldfekimhtrkrhqd
mfqdlnrklqhaaekdkevlgpdskpekqqtpnkrpweslrkahgtptwv
kkeleplqpsplelrsvewersgatiplvgqdiidlqtev
Calculated Isoelectric Point:
0
Molecular Weight:
1760
Last Updated:
10/24/2019
Links
- EnsEMBL - EnsEMBL BAI1
- Entrez - Entrez BAI1
- Uniprot - Uniprot O14514
Characterization Data
SOPs
No SOPs available.
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