Brain-Specific Angiogenesis Inhibitor 1 Peptide 1


Background

Catalog Number:

CPTC-BAI1-1

Target Antigen:

Brain-Specific Angiogenesis Inhibitor 1 Peptide 1

Isotype:

IgG3

Species:

Mouse Monoclonal Antibody

Last Updated:

11/14/2019

Antigen Recognition(s):

Peptide

SOP:

Purchase
Characterization Data [Compare Characterization Data]
  IPMS
Click to enlarge image Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-1 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen. Click image to enlarge

CPTC-BAI1-1 IPMS

Result: Positive

Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-1 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen.


Background

Catalog Number:

CPTC-BAI1-2

Target Antigen:

Brain-Specific Angiogenesis Inhibitor 1 Peptide 1

Isotype:

IgG3

Species:

Mouse Monoclonal Antibody

Last Updated:

11/14/2019

Antigen Recognition(s):

Peptide

SOP:

Purchase
Characterization Data [Compare Characterization Data]
  IPMS
Click to enlarge image Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-2 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen. Click image to enlarge

CPTC-BAI1-2 IPMS

Result: Positive

Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-2 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen.


Background

Catalog Number:

CPTC-BAI1-3

Target Antigen:

Brain-Specific Angiogenesis Inhibitor 1 Peptide 1

Isotype:

IgG2b

Species:

Mouse Monoclonal Antibody

Last Updated:

11/14/2019

Antigen Recognition(s):

Peptide

SOP:

Purchase
Characterization Data [Compare Characterization Data]
  IPMS
Click to enlarge image Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-3 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen. Click image to enlarge

CPTC-BAI1-3 IPMS

Result: Positive

Immuno-Precipitation Mass Spectrometry using CPTC-BAI1-3 antibody with CPTC-BAI1 peptide 1 (NCI 00083) as the target antigen.


Background

NCI Identification Number:

00083

Antigen Name:

Brain-Specific Angiogenesis Inhibitor 1 Peptide 1

CPTC Name:

CPTC-BAI1 Peptide 1

Keywords:

Brain-Specific Angiogenesis Inhibitor 1; GDAIF

Function:

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.

BAI1 (brain-specific angiogenesis inhibitor 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is UNC5B.

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.

Chromosomal Localization:

8q24.3

NCBI Accession Number:

NP_001693.2

Swiss Prot Accession Number:

O14514

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

QFDSFLESTRTYLGVE

Native Sequence:

mrgqaaapgpvwilapllllllllgrraraaagadagpgpepcatlvqgk
ffgyfsaaavfpanasrcswtlrnpdprrytlymkvakapvpcsgpgrvr
tyqfdsflestrtylgvesfdevlrlcdpsaplaflqaskqflqmrrqqp
pqhdglrpragppgptddfsveylvvgnrn psraacqmlcrwldaclag
srsshpcgimqtpcaclggeaggpaagplaprgdvclrdavaggpenclt
sltqdrgghgatggwklwslwgectrdcggglqtrtrtclpapgvegggc
egvleegrqcnreacgpagrtssrsqslrstdarrreelgdelqqfgfpa
pqtgdpaaeew spwsvcsstcgegwqtrtrfcvsssystqcsgplreq
rlcnnsavcpvhgawdewspwslcsstcgrgfrdrtrtcrppqfggnpce
gpekqtkfcnialcpgravdgnwnewsswsacsascsqgrqqrtrecngp
syg gaecqghwvetrdcflqqcpvdgkwqawaswgscsvtcgagsqrre
rvcsgpffggaacqgpqdeyrqcgtqrcpepheicdednfgaviwketpa
gevaavrcprnatglilrrceldeegiaywepptyircvsidyrniqmmt
rehlakaqrglpgegvseviqtlveisqdgtsysgdllstidvlrnmtei
frrayysptpgdvqnfvqilsnllaeenrdkweeaqlagpnakelfrlve
dfvdvigfrmkdlrdayqvtdnlvlsihklpasgatdisfpmkgwratgd
wakvpedrvtvsksvfstglteadeasvfvvgtvlyrnlgsflalqrntt
vlnskvisvtvkppprslrtpleiefahmyngttnqtcilwdetdvpsss
appqlgpwswrgcrtvpldalrtrclcdrlstfailaqlsadanmekatl
psvtlivgcgvssltllmlviiyvsvwryirsersvilinfclsiissna
liligqtqtrnkvvctlvaaflhffflssfcwvlteawqsymavtghlrn
rlirkrflclgwglpalvvaisvgftkakgystmnycwlslegg llyaf
vgpaaavvlvnmvigilvfnklvskdgitdkklkeragaslwsscvvlpl
laltwmsavlavtdrrsalfqilfavfdslegfvivmvhcilrrevqdav
kcrvvdrqeegngdsggsfqnghaqlmtdfekdvdlacrsvlnkdiaacr
tatitgtlkrpslpeeeklklahakgpptnfnslpanvsklhlhgspryp
ggplpdfpnhsltlkrdkapkssfvgdgdifkkldselsraqekaldtsy
vilptatatlrpkpkeepkysihidqmpqtrlihlstapeaslparspps
rqppsggppeappaqppppppppppppqqplppppnlepappslgdpgep
aahpgpstgpstknenvatlsvssl errksryaeldfekimhtrkrhqd
mfqdlnrklqhaaekdkevlgpdskpekqqtpnkrpweslrkahgtptwv
kkeleplqpsplelrsvewersgatiplvgqdiidlqtev

Calculated Isoelectric Point:

0

Molecular Weight:

1760

Last Updated:

10/24/2019

Links

Characterization Data

SOPs

No SOPs available.

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