ATR Interacting Protein Peptide 2


Background

Catalog Number:

CPTC-ATRIP-2

Target Antigen:

ATR Interacting Protein Peptide 2

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

10/10/2019

Antigen Recognition(s):

Peptide

SOP:

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-ATRIP-2 antibody (see CPTAC assay portal for details:  https://assays.cancer.gov/CPTAC-3217) Click image to enlarge

CPTC-ATRIP-2 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-ATRIP-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3217)


Background

NCI Identification Number:

00193

Antigen Name:

ATR Interacting Protein Peptide 2

CPTC Name:

CPTC-ATRIP Peptide 2

Keywords:

ATR Interacting Protein; ATM And Rad3-Related-Interacting Protein; AGS1

Function:

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

ATRIP (ATR Interacting Protein) is a Protein Coding gene. Diseases associated with ATRIP include Seckel Syndrome and Seckel Syndrome 8. Among its related pathways are Fanconi anemia pathway and E2F mediated regulation of DNA replication. GO annotations related to this gene include nucleic acid binding and K63-linked polyubiquitin binding.

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

Chromosomal Localization:

3p21.31

NCBI Accession Number:

NP_001257951.1

Swiss Prot Accession Number:

Q8WXE1

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

L(pS)DGDMTSALR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1210

Last Updated:

02/16/2017

Links

Characterization Data

SOPs

No SOPs available.

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