APEX Nuclease I
Mouse Monoclonal Antibody
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Tissue Micro-Array(TMA) core of ovarian cancer showing nuclear staining using Antibody CPTC-APEX1-2. Titer: 1:5000
Indirect ELISA (ie, binding of Antibody to Antigen coated plate)
Protein Array in which CPTC-APEX1-2 is screened against the NCI60 cell line panel for expression. Data is normalized to a mean signal of 1.0 and standard deviation of 0.5. Color conveys over-expression level (green), basal level (blue), under-expression level (red).
Western Blot using CPTC-APEX1-2 as primary Ab against Ag 10750 (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
NCI Identification Number:
APEX Nuclease I
APE; APE-1; APE1; APEN; APEX, APX; HAP1; EC 184.108.40.206; REF1; REF-1; OTTHUMP00000163988
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin
NCBI Accession Number:
UniProt Accession Number:
Recombinant Full Length Protein
HIP : HsCD00003335
Calculated Isoelectric Point:
PAGE of APEX1 (Ag 10750) with molecular weight standards (lane 1)
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