ATP Binding Cassette Subfamily B Member 1 Peptide 2


Background

Catalog Number:

CPTC-ABCB1-4

Target Antigen:

ATP Binding Cassette Subfamily B Member 1 Peptide 2

Isotype:

IgG2b

Species:

Mouse Monoclonal Antibody

Last Updated:

08/02/2019

Antigen Recognition(s):

Peptide

SOP:

Characterization Data [Compare Characterization Data]
  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-ABCB1-4 Indirect ELISA

Result: Positive

Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.


Characterization SOP Files

  NCI 60 Protein Array
Click to enlarge image This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105. Click image to enlarge

CPTC-ABCB1-4 NCI 60 Protein Array

Result: Positive

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.


Background

Catalog Number:

CPTC-ABCB1-5

Target Antigen:

ATP Binding Cassette Subfamily B Member 1 Peptide 2

Isotype:

IgG2b

Species:

Mouse Monoclonal Antibody

Last Updated:

10/24/2019

Antigen Recognition(s):

Peptide

SOP:

Characterization Data [Compare Characterization Data]
  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-ABCB1-5 Indirect ELISA

Result: Positive

Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.


Characterization SOP Files

  NCI 60 Protein Array
Click to enlarge image This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105. Click image to enlarge

CPTC-ABCB1-5 NCI 60 Protein Array

Result: Positive

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.


Background

Catalog Number:

CPTC-ABCB1-6

Target Antigen:

ATP Binding Cassette Subfamily B Member 1 Peptide 2

Isotype:

IgG2b

Species:

Mouse Monoclonal Antibody

Last Updated:

08/02/2019

Antigen Recognition(s):

Peptide

SOP:

Characterization Data [Compare Characterization Data]
  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-ABCB1-6 Indirect ELISA

Result: Positive

Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.


Characterization SOP Files

  NCI 60 Protein Array
Click to enlarge image This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105. Click image to enlarge

CPTC-ABCB1-6 NCI 60 Protein Array

Result: Positive

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.


Background

NCI Identification Number:

00258

Antigen Name:

ATP Binding Cassette Subfamily B Member 1 Peptide 2

CPTC Name:

CPTC-ABCB1 Peptide 2

Keywords:

ATP Binding Cassette Subfamily B Member 1; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1; Multidrug Resistance Protein 1; Colchicin Sensitivity; P-Glycoprotein 1; EC 3.6.3.44; MDR1; PGY1; ATP-Binding Cassette Sub-Family B Member 1; P Glycoprotein; CD243 Antigen; EC 3.6.3; ABC20; CD243; GP170; P-GP; CLCS

Function:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. Diseases associated with ABCB1 include Colchicine Resistance and Inflammatory Bowel Disease 13. Among its related pathways are Abacavir transport and metabolism and Vinka Alkaloid Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCB4.

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.

Chromosomal Localization:

7q21.12

NCBI Accession Number:

NM_000927.4

UniProt Accession Number:

P08183

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

NITNRSDINDTGFFMNLEEDM

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

2310

Last Updated:

10/01/2019

Links

Characterization Data

SOPs

No SOPs available.

Don't have Adobe Reader™?

Get it for free at Adobe.com