Glutathione S-Transferase Pi 1 Peptide 1


Background

Catalog Number:

CPTC-GSTP1-1

RRID:

AB_2617266

Target Antigen:

Glutathione S-Transferase Pi 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

10/20/2023

Antigen Recognition(s):

Peptide

Thematic Panel(s):

DNA Damage Response (DDR) Pathway

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Characterization Data [Compare Characterization Data]
  IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (465.3 KB)

CPTC-GSTP1-1 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-GSTP1-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3231) 

Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html) Click image to enlarge

CPTC-GSTP1-1 IMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-GSTP1-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3231)

Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)


  Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (465.3 KB)

CPTC-GSTP1-1 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to Peptide coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-GSTP1-1 Indirect ELISA (peptide)

Result: Positive

Indirect ELISA (ie, binding of Antibody to Peptide coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.


Characterization SOP Files

Background

NCI Identification Number:

00028

Antigen Name:

Glutathione S-Transferase Pi 1 Peptide 1

CPTC Name:

CPTC-GSTP1 Peptide 1

Aliases:

GST3; FAEES3; GSTP; GSTP1-1; GST Class-Pi; EC 2.5.1.18; DFN7; PI; Deafness, X-Linked 7; Fatty Acid Ethyl Ester Synthase III; Glutathione S-Transferase P

Function:

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic, xenobiotic substrates, thus aiding excretion from the body.

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Chromosomal Localization:

11q13.2

Accession Number:

AY324387.1

UniProt Accession Number:

P09211

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

YISLIYTNYEAGK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1430

Last Updated:

06/11/2013

Links

Characterization Data

SOPs

No SOPs available.

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