NCKAP2; Protein Ash; ASH; SH2/SH3 Adapter GRB2; EGFRBP-GRB2; Grb3-3; HT027; MST084; MSTP084; Abundant SRC Homology; Epidermal Growth Factor Receptor-Binding; Protein GRB2; Growth Factor Receptor Bound Protein 3; Adapter Protein GRB2
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3
domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras
Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.