NCI Identification Number:
EPH receptor B4
EPH receptor B4; HTK; MYK1; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11; TYRO11; EC 18.104.22.168; EPHB4; ephrin type-B receptor 4; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; tyrosine-protein kinase receptor HTK; EC 2.7.10
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous
system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class,
which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are
transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their
extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent
cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Ephrins are a family of receptor tyrosine kinases (RTKs) that influence cell migration. In conjunction with the ephrin ligands, ephrin receptors are involved in a variety of developmental events. EphB4 is overexpressed in many tumor types, including breast and prostate cancer.
NCBI Accession Number:
Swiss Prot Accession Number:
DNASU - HsCD00021508
PBS without Ca++ and Mg++
Calculated Isoelectric Point:
Click to enlarge
PAGE of EPHB4 (rAg 10657) with molecular weight standards in lane 1