Catalog Number:
CPTC-UBE2I-1
RRID:
AB_2888974
Target Antigen:
Ubiquitin Conjugating Enzyme E2I Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
08/24/2022
Antigen Recognition(s):
Peptide, Recombinant Full-length
Thematic Panel(s):
DNA Damage Response (DDR) Pathway
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Immuno-MRM chromatogram of CPTC-UBE2I-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3261)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)
Result: Positive
Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Positive
Indirect ELISA (ie, binding of Antibody to full-length Antigen coated on plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Positive
Western Blot using CPTC-UBE2I-1 as primary Ab against full-length recombinant Ag 10319 (lane 2). Also included are molecular wt. standards (lane 1) and the UBE2I-1 Ab as positive control (lane 3).
NCI Identification Number:
00045
Antigen Name:
Ubiquitin Conjugating Enzyme E2I Peptide 1
CPTC Name:
CPTC-UBE2I Peptide 1
Aliases:
UBC9; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin-Protein Ligase I; SUMO-Protein Ligase; C358B7.1; P18; SUMO-1-Protein Ligase; SUMO-Conjugating Enzyme UBC9; Ubiquitin Conjugating Enzyme 9; Ubiquitin-Conjugating Enzyme; UbcE2A; Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme; Ubiquitin-Protein Ligase E2I; EC 6.3.2; UBCE9
Function:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the
E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have
been found for this gene.
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and
catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can
catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear
architecture and chromosome segregation.
Chromosomal Localization:
16p13.3
Accession Number:
NP_003336.1
UniProt Accession Number:
P63279
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
DHPFGFVAVPTK
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
1320
Last Updated:
06/21/2013
No SOPs available.
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