Background
Catalog Number:
CPTC-RAD51C-1
Target Antigen:
RAD51 Paralog C Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
07/14/2022
Antigen Recognition(s):
Peptide, Phosphorylation
Thematic Panel(s):
DNA Damage Response (DDR) Pathway
External Links
- CPTAC Assay Portal CPTAC-3287
Purchase
- DSHB CPTC-RAD51C-1
Publications
Characterization Data [Compare Characterization Data]
Immuno-MRM
CPTC-RAD51C-1 IMRM
Result: Positive
Immuno-MRM chromatogram of CPTC-RAD51C-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3287)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)
Characterization SOP Files
Background
Catalog Number:
CPTC-RAD51C-2
RRID:
AB_2889062
Target Antigen:
RAD51 Paralog C Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
07/14/2022
Antigen Recognition(s):
Peptide
Thematic Panel(s):
DNA Damage Response (DDR) Pathway
External Links
- CPTAC Assay Portal CPTAC-3250
Purchase
- DSHB CPTC-RAD51C-2
Publications
Characterization Data [Compare Characterization Data]
Immuno-MRM
CPTC-RAD51C-2 IMRM
Result: Positive
Immuno-MRM chromatogram of CPTC-RAD51C-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3250)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)
Characterization SOP Files
Background
NCI Identification Number:
00104
Antigen Name:
RAD51 Paralog C Peptide 1
CPTC Name:
CPTC-RAD51C Peptide 1
Aliases:
RAD51 Paralog C; DNA Repair Protein RAD51 Homolog 3; R51H3; RAD51L2; RAD51 Like protein 2; BROVCA3; FANCO; RAD51; Rad51 Homolog C; RAD51 Homolog C; Yeast RAD51 Homolog 3
Function:
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants.
RAD51C (RAD51 paralog C) is a protein-coding gene. Diseases associated with RAD51C include fanconi anemia, complementation group o, and rad51c-related familial susceptibility to breast-ovarian cancer. GO annotations related to this gene include DNA-dependent ATPase activity and crossover junction endodeoxyribonuclease activity. An important paralog of this gene is DMC1.
Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by
DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2
complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the
presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis
Chromosomal Localization:
17q22
Accession Number:
NP_002867.1
UniProt Accession Number:
O43502
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
DLVSFPL(pS)PAVR (pS20)
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
1320
Last Updated:
03/11/2015
Links
- EnsEMBL - EnsEMBL RAD51C
- Entrez - Entrez RAD51C
- Uniprot - Uniprot O43502
Characterization Data
SOPs
No SOPs available.
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