Background
Catalog Number:
CPTC-FSCN1-1
RRID:
AB_1553796
Target Antigen:
Fascin 1, Actin-Bundling Protein Peptide 1
Isotype:
IgG
Species:
Rabbit Recombinant Cloned Antibody
Last Updated:
02/06/2024
Antigen Recognition(s):
Peptide, Endogenous
External Links
- CPTAC Assay Portal CPTAC-709
Purchase
- DSHB CPTC-FSCN1-1
External Links
- Human Protein Atlas CPTC-FSCN1-1
Publications
Characterization Data [Compare Characterization Data]
IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (448.9 KB)
CPTC-FSCN 1-1 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Immuno-MRM
CPTC-FSCN 1-1 iMRM
Result: Positive
Immuno-MRM chromatogram of CPTC-ATM-1 antibody (see CPTAC assay portal for details: (https://assays.cancer.gov/CPTAC-709)
Immunofluorescence - HPA
CPTC-FSCN 1-1 evaluation by the Human Protein Atlas
Result: Positive
Results provided by the Human Protein Atlas (www.proteinatlas.org). The subcellular location is supported by literature. Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane & centriolar satellites.
Human assay: THP-1 fixed with PFA, dilution: 1:100
Human assay: U2OS fixed with PFA, dilution: 1:100
Characterization SOP Files
Western Blot - HPA - tissue or cell lysate
CPTC-FSCN 1-1 evaluation by the Human Protein Atlas
Result: Positive
Results provided by the Human Protein Atlas (www.proteinatlas.org). Band of predicted size in kDa (+/-20%) with additional bands present.
Analysis performed using a standard panel of samples. Antibody dilution: 1:500
Characterization SOP Files
Background
NCI Identification Number:
00041
Antigen Name:
Fascin 1, Actin-Bundling Protein Peptide 1
CPTC Name:
CPTC-FSCN1 Peptide 1
Aliases:
SNL; P55; 55 KDa Actin-Bundling Protein; FAN1; HSN; FLJ38511; Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like); Fascin; Singed-Like (Fascin Homolog, Sea Urchin); Singed-like protein
Function:
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into arallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a ritical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be egulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of
cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's ymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the
organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers.
Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and
migration
Chromosomal Localization:
7p22
Accession Number:
NP_003079.1
UniProt Accession Number:
Q16658
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
YLAPSGPSGTLK
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
1320
Last Updated:
07/18/2019
Links
- EnsEMBL - EnsEMBL FSCN1
- Entrez - Entrez FSCN1
- Uniprot - Uniprot Q16658
Characterization Data
SOPs
No SOPs available.
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