Catalog Number:
CPTC-Ezrin-2
RRID:
AB_2888949
Target Antigen:
Ezrin Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
03/20/2024
Antigen Recognition(s):
Peptide, Recombinant Full-length, Endogenous
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Immuno-MRM chromatogram of CPTC-Ezrin-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-712)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html). Data shown were obtained from plasma.
Result: Positive
Indirect peptide ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Positive
Western Blot using CPTC-EZRIN-2 as primary Ab against full-length recombinant Ag 10474 (lane 2). Also included are molecular wt. standards (lane 1) and the EZRIN-2 Ab as positive control (lane 3).
NCI Identification Number:
00047
Antigen Name:
Ezrin Peptide 1
CPTC Name:
CPTC-Ezrin Peptide 1
Aliases:
EZR; VIL2; Villin 2 (Ezrin); CVL; P81; CVIL; Cytovillin 2; Villin-2; Cytovillin
Function:
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial
cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis
Chromosomal Localization:
6q25.3
Accession Number:
NP_001104547.1
UniProt Accession Number:
P15311
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
SGYLSSER
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
880
Last Updated:
06/21/2013
No SOPs available.
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