Catalog Number:
CPTC-CD44-1
Target Antigen:
CD44 molecule (Indian blood group) Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
03/20/2024
Antigen Recognition(s):
Peptide, Recombinant Full-length, Endogenous
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Immuno-MRM chromatogram of CPTC-CD40-4 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-692)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html). Data shown were obtained from plasma.
Result: Positive
Indirect ELISA (ie, binding of Antibody to Peptide coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Positive
Indirect ELISA (ie, binding of Antibody to full-length Antigen coated on plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Result: Positive
Western Blot using CPTC-CD44-1 as primary Ab against HEK293T cell lysate containing CD44 (from Origene) in lane 2. Also included are molecular wt. standards (lane 1) and the CD44-1 Ab as the IgG control (lane 3).
NCI Identification Number:
00018
Antigen Name:
CD44 molecule (Indian blood group) Peptide 1
CPTC Name:
CPTC-CD44 Peptide 1
Aliases:
CD44 Antigen; GP90 Lymphocyte Homing/Adhesion Receptor; Hermes Antigen; CD44R; CD44 Antigen (Homing Function And Indian Blood Group System); CDW44; Cell Surface Glycoprotein CD44; Chondroitin Sulfate Proteoglycan 8; Epican; Hematopoietic Cell E- And L-Selectin Ligand; Homing Function And Indian Blood Group System; CDw44; PGP-1; Phagocytic Glycoprotein I; MDU2; MDU3; MIC4; CSPG8; HCELL; MC56; IN; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Hyaluronate Receptor; ECMR-III; HUTCH-I; LHR; Soluble CD44; CDW44; CD44
Function:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Superficial Keratitis and Intraductal Papilloma. Among its related pathways are Degradation of the extracellular matrix and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and cytokine receptor activity. An important paralog of this gene is LYVE1.Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).
Chromosomal Localization:
11p13
Accession Number:
NP_000601.3
UniProt Accession Number:
P16070
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
TFIPVTSAK
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
990
Last Updated:
09/02/2020
No SOPs available.
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