Catalog Number:
CPTC-ATRIP-1
RRID:
AB_2888945
Target Antigen:
ATR Interacting Protein Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
01/04/2023
Antigen Recognition(s):
Peptide, Endogenous, Phosphorylation
Thematic Panel(s):
DNA Damage Response (DDR) Pathway
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Immuno-MRM chromatogram of CPTC-ATRIP-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3216)
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)
Result: Positive
Results provided by the Human Protein Atlas (www.proteinatlas.org). Single band corresponding to the predicted size in kDa (+/-20%). Analysis performed using a standard panel of samples. Antibody dilution: 1:500
NCI Identification Number:
00192
Antigen Name:
ATR Interacting Protein Peptide 1
CPTC Name:
CPTC-ATRIP Peptide 1
Aliases:
ATR Interacting Protein; ATM And Rad3-Related-Interacting Protein; AGS1
Function:
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
ATRIP (ATR Interacting Protein) is a Protein Coding gene. Diseases associated with ATRIP include Seckel Syndrome and Seckel Syndrome 8. Among its related pathways are Fanconi anemia pathway and E2F mediated regulation of DNA replication. GO annotations related to this gene include nucleic acid binding and K63-linked polyubiquitin binding.
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Chromosomal Localization:
3p21.31
Accession Number:
NP_001257951.1
UniProt Accession Number:
Q8WXE1
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
LAAPSVSHV(pS)PR (pS224)
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
1320
Last Updated:
02/16/2017
No SOPs available.
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