SM22; WS3-10; SMCC; TAGLN1; Smooth Muscle Protein 22-Alpha; 22 KDa Actin-Binding Protein; SM22-Alpha; DKFZp686P11128; Transgelin Variant 2; Protein WS3-10
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile
properties of the cell that may contribute to replicative senescence.