Western Blot using CPTC-SNCG-1 as primary Ab against Ag 10504 (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
Western Blot using CPTC-SNCG-2 as primary Ab against Ag 10504 (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
Synuclein-gamma is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity)