Western Blot using CPTC-S100A2-1 as primary Ab against S100A2 (Ag 11011) (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
Western Blot using CPTC-S100A2-2 as primary Ab against S100A2 (Ag 11011) (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
Western Blot using CPTC-S100A2-3 as primary Ab against S100A2 (Ag 11011) (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer.
May act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. May also play a role in suppressing tumor cell growth.