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Peroxiredoxin 2 Peptide 1

Antibody: CPTC-PRDX2-1

Background

Catalog Number:
CPTC-PRDX2-1
Target Antigen:
Peroxiredoxin 2 Peptide 1
Isotype:
IgG
Species:
Rabbit
Last Updated:
04/02/2015
Antigen Recognition(s):
peptide, recombinant full-length, native protein

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Characterization Data [Compare Characterization Data]

Western Blot

Click to enlarge image Western Blot using CPTC-PRDX2-1 as primary Ab against full-length recombinant Ag 10333 (lane 2). Also included are molecular wt. standards (lane 1) and the PRDX2-1 Ab as positive control (lane 3).
Click to enlarge

CPTC-PRDX2-1 Western Blot

Western Blot using CPTC-PRDX2-1 as primary Ab against full-length recombinant Ag 10333 (lane 2). Also included are molecular wt. standards (lane 1) and the PRDX2-1 Ab as positive control (lane 3).

Cell Lysate Western Blot

Click to enlarge image Western Blot using CPTC-PRDX2-1 as primary Ab against lysates from six breast cancer cell lines from the NCI60 cell line collection (lanes 2-7). Also included are molecular wt. standards (lane 1).
Click to enlarge

CPTC-PRDX2-1 NCI60 Western blot

Western Blot using CPTC-PRDX2-1 as primary Ab against lysates from six breast cancer cell lines from the NCI60 cell line collection (lanes 2-7). Also included are molecular wt. standards (lane 1).

Indirect ELISA

Click to enlarge image Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Click to enlarge

CPTC-PRDX2-1 Indirect ELISA (peptide)

Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.

Characterization SOP Files

Indirect ELISA

Click to enlarge image Indirect ELISA (ie, binding of Antibody to full-length Antigen coated on plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.
Click to enlarge

CPTC-PRDX2-1 Indirect ELISA

Indirect ELISA (ie, binding of Antibody to full-length Antigen coated on plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.

Antigen: Peroxiredoxin 2 Peptide 1

Background

NCI Identification Number:
00043
Antigen Name:
Peroxiredoxin 2 Peptide 1
CPTC Name:
CPTC-PRDX2 Peptide 1
Keywords:
NKEFB; PRP; TDPX1; TSA; PRX2; PRXII; Natural Killer Cell-Enhancing Factor B; Thioredoxin-Dependent Peroxide Reductase 1; NKEF-B; EC 1.11.1.15; MGC4104; PTX1; TPX1; Peroxiredoxin-2; Thiol-Specific Antioxidant 1; Torin; EC 1.11.1
Function:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the
thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Chromosomal Localization:
19p13.2
Expression System:
NCBI Accession Number:
NP_005800.3
Swiss Prot Accession Number:
P32119
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
LSEDYGVLK
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
990
Last Updated:
06/21/2013

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Characterization Data

SOPs

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