CD44 Antigen; GP90 Lymphocyte Homing/Adhesion Receptor; Hermes Antigen; CD44R; CD44 Antigen (Homing Function And Indian Blood Group System); CDW44; Cell Surface Glycoprotein CD44; Chondroitin Sulfate Proteoglycan 8; Epican; Hematopoietic Cell E- And L-Selectin Ligand; Homing Function And Indian Blood Group System; CDw44; Epican; PGP-1; Phagocytic Glycoprotein I; MDU2; MDU3; MIC4; CSPG8; HCELL; MC56; IN; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Hyaluronate Receptor; ECMR-III; HUTCH-I; LHR
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.